Alexa and Katie are two friends from their childhood, also they plan to go to the same high school and they can't wait to start their first day at it. Unfortunately Alexa exposed to a serious illness which named cancer.
Alexa & Katie is probably pitched at tweens and pre-tweens with high school dreams and their parents who don't mind leaving those kids with 13 episodes of unremarkable, uncontroversial, completely well-intentioned programming.
As a comedy, Alexa & Katie is about average, or a little below, if graded against the cable shows it resembles. But it's a little more tough-minded than you might expect.
Overall, the show's charismatic and peppy ensemble is what makes these storylines work, especially because the show is incredibly silly, sometimes painfully.